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Department of Oral and Maxillofacial Surgery, Second Hospital, Hebei Medical University, published a paper to evaluate the titanium samples by 12.5 g /L hydrofluoric acid (HF) etching treatment of different time after the formation of two different surfaces of bone marrow mesenchymal stem cells (BMMSCs). It was found that the microstructure of nanostructured titanium nanotubes was fabricated by HF etching, and the bioactivity of BMMSCs on pure titanium surface was promoted by the addition of fluorine. The article published on 2015 08 "tooth pulp periodontal disease magazine".

The pure titanium was divided into 3 groups: group A was polished; group B was 12.5 g /L HF for 1 min; group C was 12.5 g /L HF for 15 min. The surface chemical composition of the sample was analyzed by X-ray energy dispersive spectroscopy (EDS). The contact angle of the sample surface was measured by hydrophilicity test. The adhesion of BMMSCs on the sample surface was observed by laser scanning confocal microscopy. The surface morphology and adherent cells The activity of ALP was detected by alkaline phosphatase (ALP) assay.

The surface contact angle after acid etching was significantly smaller than that of the polishing group, and the C group was smaller than that of the B group. After etching, the surface of pure titanium sample Can promote adhesion, proliferation and ALP activity of BMMSCs, and C group is better than B group.