Potassium fluoride,anhydrous
           Potassium fluoride,extra pure
           Potassium fluoride,Granular
           Silicon Dioxide
           Hydrofluoric acid
           Synthetic Cryolite
           Potassium Fluoaluminate
           Ammonium bifluoride
           Potassium Bifluoride
           Aluminium fluoride
           Sodium fluoride
           Potassium Fluorosilicate
           Fluorosilicic Acid
           Sodium silicofluoride
           Potassium Hydroxide Flakes
           Magnesium Fluoride
           Magnesium fluorosilicate
           Barium Fluoride
           More
 
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The application of grinding method in solid-phase organic synthesis has been developing rapidly in the past two or three decades. It is more convenient and easy to operate than the traditional organic synthesis method. The reaction can be carried out under mild conditions, either by increasing the yield, or by shortening the reaction time, and even causing some reactions that can not be carried out under conventional conditions. This chapter reviews some recent advances in the application of dry grinding in the dry synthesis of organic grinding in recent years.

This chapter mainly studies the effects of chalcone and active methylene compounds catalyzed by potassium fluoride on alkaline alumina, such as diethyl malonate, phenylacetonitrile, malononitrile, acetoacetic acid Ethyl ester, cyclohexanone and the like, and the reaction is completed in 20 to 90 minutes to obtain a Michael addition product in a yield of 20% to 98%. The method has the advantages of mild reaction conditions, simple operation, environment - friendly and recoverable catalyst. Compared with the traditional synthesis method, the reaction time is shortened and the higher yield of Michael addition products is obtained.