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Calcium gluconate gel is standard practice to treat Hydrofluoric acid burns in most centres despite there being no controlled studies involving humans showing any benefit or to guide protocol. Calcium gluconate gel can be made in the emergency department with a water-soluble lubricant, such as K-Y Jelly (Johnson & Johnson, USA), added to calcium gluconate solution or calcium gluconate powder (75 mL K-Y Jelly plus 25 mL of 10% calcium gluconate or 100 mL of K-Y Jelly plus 2.5 g of calcium gluconate).

Animal-control studies have shown mixed results for calcium gluconate injection on Hydrofluoric acid(HF) burn healing outcomes. Nevertheless, emergency room physicians and surgeons have widely adopted its use for HF burns, likely because it has been shown in humans to reliably reduce pain after injection. The protocol first described by Dibbell et al used a 27-gauge needle to inject a 5% to 10% calcium gluconate solution into subcutaneous tissue within and beneath the burn (injecting 0.5 mL/cm2 of burn surface area).

Hydrofluoric acid injury has special and potentially dangerous, its low concentration and small area can cause serious skin damage. Symptoms can cause systemic poisoning and fatal low hypercalcemia. To improve the understanding of the injury after the hydrofluoric acid, hydrofluoric acid burns we observed the effects on the myocardium and cardiac enzymes, the results reported below.